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dc.contributor.authorCallai, Etiane Micheli Meyer-
dc.contributor.authorScarabelot, Vanessa Leal-
dc.contributor.authorMedeiros, Liciane Fernandes-
dc.contributor.authorOliveira, Carla de-
dc.contributor.authorSouza, Andressa de-
dc.contributor.authorMacedo, Isabel Cristina-
dc.contributor.authorCioato, Stefania Giotti-
dc.contributor.authorFinamor, Fabrício-
dc.contributor.authorCaumo, Wolnei-
dc.contributor.authorQuevedo, Alexandre da Silva-
dc.contributor.authorTorres, Iraci L. S.-
dc.identifier.citationCALLAI, E. M. M. et al. Transcranial direct current stimulation (tDCS) and trigeminal pain: A preclinical study. Oral Diseases, v. 25, n. 3, p. 888-897, 2019. Disponível em: Acesso em: 02 ago. 2021.pt_BR
dc.description.abstractObjective Our objective was to evaluate the Transcranial direct current stimulation (tDCS) effect on facial allodynia induced by chronic constriction of the infraorbital nerve (CCI-ION) and on the brainstem levels of TNF-α, NGF, IL-10, and serum LDH in rats. Methods Rats were exposed to the CCI-ION model. Facial allodynia was assessed by von Frey filaments test at baseline, 3, 7, 10, and 14 days postsurgery and 24 hr and 7 days after the bimodal tDCS sessions for 20 min/day/8 days. Results Chronic constriction of the infraorbital nerve induced a significant decrease in the mechanical threshold 14 days after surgery. This effect was reversed by tDCS treatment, with the mechanical threshold returning to basal levels at 24 hr after the end of the treatment and it persisted for 7 days after the end of the treatment. tDCS also decreased LDH serum levels compared to those in the control group. There was an interaction between pain and treatment with respect to brainstem levels of NGF, TNF-α, and IL-10. Conclusion Chronic constriction of the infraorbital nerve model was effective in establishing trigeminal neuropathic pain on 14 days after surgery, and tDCS reduced allodynia and LDH serum levels and promoted alterations in NGF, TNF-α, and IL-10 brainstem levels. Thus, we suggest that tDCS may be a potential therapy in the trigeminal pain treatment.pt_BR
dc.rightsOpen Accessen
dc.subjectTrigeminal neuralgiapt_BR
dc.titleTranscranial direct current stimulation (tDCS) and trigeminal pain: A preclinical studypt_BR
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