Please use this identifier to cite or link to this item: http://hdl.handle.net/11690/2179
Authors: Oliveira, Carla
Toledo, Roberta Ströher
Scarabelot, Vanessa Leal
Vercelino, Rafael
Silva, Lisiane Santos da
Regner, Gabriela Gregory
Souza, Andressa de
Silveira, Natalia Paula
Caumo, Wolnei
Torres, Iraci L. S.
Title: Neonatal morphine exposure and maternal deprivation alter nociceptive response and central biomarkers’ levels throughout the life of rats
Keywords: Opioid;Maternal-separation;Neonate rats;Nociception
Issue Date: 2020
Publisher: Elsevier
Citation: OLIVEIRA, C. et al. Neonatal morphine exposure and maternal deprivation alter nociceptive response and central biomarkers’ levels throughout the life of rats. Neuroscience Letters, v. 738, 2020. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0304394020306200?via%3Dihub. Acesso em: 14 set. 2021.
Abstract: In the present study, we investigated the effect of repeated neonatal morphine exposure and/or maternal deprivation(MD) on the nociceptive response and central biomarkers’ BDNF, IL-1β, and IL-4 levels at postnatal days 16(PND16), 30(PND30), and 60(PND60). At birth, the litters were standardized to contain 8 pups/dam (n = 58). From PND1 to PND10, the pups of the deprived groups were separated daily from their mothers for 3 h and divided into 5 groups: control(C), saline(S), morphine(M), deprived-saline(DS), and deprived-morphine(DM). The pups received subcutaneous injections of saline/morphine (5 μg) in the mid-scapular area between PND8 and PND14. Nociceptive responses were assessed by hot plate(HP) and tail-flick(TFL) tests and biomarker levels by ELISA. Thermal hyperalgesia(HP) was found in all assessments for the M, DS, and DM groups, and a decrease in nociceptive threshold(TFL) was found in the DS group at PND16; M and DM groups at PND30; and M, DS, and DM groups at PND60. There were interactions between treatment/deprivation/timepoint in all central biomarkers’ levels. The current study indicates that neonatal exposure to morphine and MD, which occurs in the pediatric ICU, can alter the nociceptive and neuroinflammatory responses.
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