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http://hdl.handle.net/11690/1917
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Campo DC | Valor | Idioma |
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dc.contributor.author | Freitas, Ana C. N. | - |
dc.contributor.author | Peigneur, Steve | - |
dc.contributor.author | Macedo, Flávio H. P. | - |
dc.contributor.author | Menezes-Filho, José E. | - |
dc.contributor.author | Millns, Paul | - |
dc.contributor.author | Medeiros, Liciane Fernandes | - |
dc.contributor.author | Arruda, Maria A. | - |
dc.contributor.author | Cruz, Jader | - |
dc.contributor.author | Holliday, Nicholas D. | - |
dc.contributor.author | Tytgat, Jan | - |
dc.contributor.author | Hathway, Gareth | - |
dc.contributor.author | Lima, Maria E. de | - |
dc.date.accessioned | 2021-08-03T14:57:03Z | - |
dc.date.available | 2021-08-03T14:57:03Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | FREITAS, A. C. N. et al. The Peptide PnPP-19, a Spider Toxin Derivative, Activates µ-Opioid Receptors and Modulates Calcium Channels. Toxins, v. 10, n. 1, jan. 2018. Disponível em: https://www.mdpi.com/2072-6651/10/1/43. Acesso em: 03 ago. 2021. | pt_BR |
dc.identifier.uri | http://hdl.handle.net/11690/1917 | - |
dc.description.abstract | The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin δ-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer. Behavioural tests suggest that PnPP-19 induces antinociception by activation of CB1, µ and δ opioid receptors. Since the peripheral and central antinociception induced by PnPP-19 involves opioid activation, the aim of this work was to identify whether this synthetic peptide could directly activate opioid receptors and investigate the subtype selectivity for µ-, δ- and/or κ-opioid receptors. Furthermore, we also studied the modulation of calcium influx driven by PnPP-19 in dorsal root ganglion neurons, and analyzed whether this modulation was opioid-mediated. PnPP-19 selectively activates µ-opioid receptors inducing indirectly inhibition of calcium channels and hereby impairing calcium influx in dorsal root ganglion (DRG) neurons. Interestingly, notwithstanding the activation of opioid receptors, PnPP-19 does not induce β-arrestin2 recruitment. PnPP-19 is the first spider toxin derivative that, among opioid receptors, selectively activates µ-opioid receptors. The lack of β-arrestin2 recruitment highlights its potential for the design of new improved opioid agonists. | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.publisher | Multidisciplinary Digital Publishing Institute | pt_BR |
dc.rights | Open Access | en |
dc.subject | Phoneutria nigriventer | pt_BR |
dc.subject | Opioid receptor | pt_BR |
dc.subject | Spider toxin | pt_BR |
dc.subject | Antinociception | pt_BR |
dc.title | The Peptide PnPP-19, a Spider Toxin Derivative, Activates µ-Opioid Receptors and Modulates Calcium Channels | pt_BR |
dc.type | Artigo | pt_BR |
Aparece nas coleções: | Artigo de Periódico (PPGSDH) |
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acnfreitas.etal.pdf | Open Access | 1,9 MB | Adobe PDF | Visualizar/Abrir |
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