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http://hdl.handle.net/11690/2738
Autor(es): | Sartor, Ivaine Tais Sauthier Varela, Fernanda Hammes Meireles, Mariana Rost Kern, Luciane Beatriz Azevedo, Thaís Raupp Giannini, Gabriela Luchiari Tumioto Silva, Mariana Soares da Demoliner, Meriane Gularte, Juliana Schons Almeida, Paula Rodrigues de Fleck, Juliane Deise Zavaglia, Gabriela Oliveira Fernandes, Ingrid Rodrigues David, Caroline Nespolode Santos, Amanda Paz Almeida, Walquiria Aparecida Ferreirade Porto, Victor Bertollo Gomes Scotta, Marcelo Comerlato Vieira, Gustavo Fioravanti Spilki, Fernando Rosado Stein, Renato T. Polese-Bonatto, Márcia |
Título: | Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction |
Palavras-chave: | COVID-19;SARS-CoV-2;Variants;Novel mutation |
Data do documento: | 2022 |
Citação: | SARTOR, I. T. S. et al. Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction. Diagnostic Microbiology and Infectious Disease, v. 102, n. 4, e115636, abr., 2022. Disponível em: https://www.sciencedirect.com/science/article/pii/S0732889322000049. Acesso em: 23 abr. 2022. |
Resumo: | We aimed to describe the SARS-CoV-2 lineages circulating early pandemic among samples with S gene dropout and characterize the receptor-binding domain (RBD) of viral spike protein. Adults and children older than 2 months with signs and symptoms of COVID-19 were prospectively enrolled from May to October in Porto Alegre, Brazil. All participants performed RT-PCR assay, and samples with S gene dropout and cycle threshold < 30 were submitted to high-throughput sequencing (HTS). 484 out of 1,557 participants tested positive for SARS-CoV-2. The S gene dropout was detected in 7.4% (36/484) and a peak was observed in August. The B.1.1.28, B.1.91 and B.1.1.33 lineages were circulating in early pandemic. The RBD novel mutation (Y380Q) was found in one sample occurring simultaneously with C379W and V395A, and the B.1.91 lineage in the spike protein. The Y380Q and C379W may interfere with the binding of neutralizing antibodies (CR3022, EY6A, H014, S304). |
Aparece nas coleções: | Artigo de Periódico (PPGSDH) |
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sartor.etal.pdf | Open Access | 2,85 MB | Adobe PDF | Visualizar/Abrir |
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