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Authors: Scovino, Aline Miranda
Dahab, Elizabeth Chen
Vieira, Gustavo Fioravanti
Freire-de-Lima, Leonardo
Freire-de-Lima, Celio Geraldo
Morrot, Alexandre
Title: SARS-Cov-2's variants of concern: a brief characterization
Keywords: COVID-19;SARS-CoV-2;COVID-19 vaccination;viral immune escape;SARS-COV-2 variants
Issue Date: 2022
Publisher: Frontiers
Citation: SCOVINO, A. M. et al. SARS-CoV-2?s Variants of Concern: A Brief Characterization. Frontiers in Immunology, v. 13, p. 1, 2022. Disponível em: Acesso em: 05 out. 2022.
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disclose the variants of concern (VOC) including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P1), Delta (B.1.617.2), and Omicron (B.1.1.529). Its spike protein (S) present on the surface of the virus is recognized by the host cell receptor, the angiotensin-2 converting enzyme (ACE2) which promotes their entry into the cell. The mutations presented by VOCs are found in RBD and the N-terminal region of S protein. Therefore, mutations occurring in RBD can modify the biological and immunogenic characteristics of the virus, such as modifying the spike affinity for ACE2, increasing the virus transmissibility, or conferring the ability to escape the immune responses. The raise of a potential new SARS-CoV-2 variant capable of evading the host defenses at the same time maintaining its fitness justifies the importance of continued genetic monitoring of the pandemic coronavirus.
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