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dc.contributor.authorMedeiros, Helouise R.-
dc.contributor.authorAssumpcao, José A. F.-
dc.contributor.authorMedeiros, Liciane Fernandes-
dc.contributor.authorStapenhorst, Martina-
dc.contributor.authorNunes, Lara-
dc.contributor.authorHenckes, Nicole A. C.-
dc.contributor.authorCruz, Carolina Uribe-
dc.contributor.authorOliveira, Fernanda S. O.-
dc.contributor.authorCaumo, Wolnei-
dc.contributor.authorCirne-Lima, Elizabeth O.-
dc.contributor.authorTorres, Iraci L. S.-
dc.identifier.citationMEDEIROS, H. R. et al. Static magnetic stimulation induces cell-type specific alterations in the viability of SH-SY5Y Neuroblastoma cell line. Anticancer Research, v.40, n. 9, p. 5151-5158, 2020. Disponível em: Acesso em: 15 fev. 2023.pt_BR
dc.description.abstractBackground/Aim: Magnetic stimulation is used in the treatment of a diversity of diseases, but a complete understanding of the underlying mechanisms of action requires further investigation. We examined the effect of static magnetic stimulation (SMS) in different cell lines. Materials and Methods: A culture plate holder with attached NeFeB magnets was developed. Different magnetic field intensities and periods were tested in tumoral and non-tumoral cell lines. To verify the cellular responses to SMS, cell viability, cell death, cell cycle and BDNF expression were evaluated. Results: Exposure of SH-SY5Y cells to SMS for 24 hours led to a decrease in cell viability. Analysis 24 h after stimulation revealed a decrease in apoptotic and double-positive cells, associated with an increase in the number of necrotic cells. Conclusion: The effects of SMS on cell viability are cell type-specific, inducing a decrease in cell viability in SH-SY5Y cells. This suggests that SMS may be a potential tool in the treatment of neuronal tumors.pt_BR
dc.publisherAnticancer Researchpt_BR
dc.rightsOpen Accessen
dc.subjectStatic magnetic stimulationpt_BR
dc.subjectCell cyclept_BR
dc.subjectCell deathpt_BR
dc.subjectCell viabilitypt_BR
dc.titleStatic magnetic stimulation induces cell-type specific alterations in the viability of SH-SY5Y Neuroblastoma cell linept_BR
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