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|Medeiros, Helouise R.
Assumpcao, José A. F.
Medeiros, Liciane Fernandes
Henckes, Nicole A. C.
Cruz, Carolina Uribe
Oliveira, Fernanda S. O.
Cirne-Lima, Elizabeth O.
Torres, Iraci L. S.
|Static magnetic stimulation induces cell-type specific alterations in the viability of SH-SY5Y Neuroblastoma cell line
|Static magnetic stimulation;Cell cycle;Cell death;Cell viability;Neuroblastoma
|MEDEIROS, H. R. et al. Static magnetic stimulation induces cell-type specific alterations in the viability of SH-SY5Y Neuroblastoma cell line. Anticancer Research, v.40, n. 9, p. 5151-5158, 2020. Disponível em: https://ar.iiarjournals.org/content/40/9/5151.long. Acesso em: 15 fev. 2023.
|Background/Aim: Magnetic stimulation is used in the treatment of a diversity of diseases, but a complete understanding of the underlying mechanisms of action requires further investigation. We examined the effect of static magnetic stimulation (SMS) in different cell lines. Materials and Methods: A culture plate holder with attached NeFeB magnets was developed. Different magnetic field intensities and periods were tested in tumoral and non-tumoral cell lines. To verify the cellular responses to SMS, cell viability, cell death, cell cycle and BDNF expression were evaluated. Results: Exposure of SH-SY5Y cells to SMS for 24 hours led to a decrease in cell viability. Analysis 24 h after stimulation revealed a decrease in apoptotic and double-positive cells, associated with an increase in the number of necrotic cells. Conclusion: The effects of SMS on cell viability are cell type-specific, inducing a decrease in cell viability in SH-SY5Y cells. This suggests that SMS may be a potential tool in the treatment of neuronal tumors.
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