Please use this identifier to cite or link to this item:
http://hdl.handle.net/11690/3738
Authors: | Rosa, Regis Goulart Cavalcanti, Alexandre Biasi Azevedo, Luciano César Pontes Veiga, Viviane Cordeiro Souza, Denise de Santos, Rosa da Rosa Minho dos Schardosim, Raíne Fogliati de Carli Rech, Gabriela Soares Trott, Geraldine Schneider, Daniel Robinson, Caroline Cabral Haubert, Tainá Aparecida Pallaoro, Victoria Emanuele Lobo Brognoli, Liége Gregoletto Souza, Ana Paula de Costa, Lauren Sezerá Barroso, Bruna Machado Pelliccioli, Melissa Pezzetti Gonzaga, Janine Studier, Nicole dos Santos Dagnino, Ana Paula Aquistapase Mesquita Neto, Juliana de Silva, Sabrina Souza da Gimenes, Bruna dos Passos Santos, Vanessa Brzoskowski dos Estivalete, Gabriel Pozza Muller Pellegrino, Carolina de Moraes Polanczyk, Carisi Anne Dourado, Letícia Kawano‑ Tomazini, Bruno Martins Lisboa, Thiago Costa Teixeira, Cassiano Zampieri, Fernando Godinho Zavascki, Alexandre Prehn Gersh, Bernard J. Avezum, Álvaro Machado, Flávia Ribeiro Berwanger, Otavio Lopes, Renato Delascio Falavigna, Maicon |
Title: | Association between acute disease severity and one-year quality of life among post-hospitalisation COVID-19 patients: Coalition VII prospective cohort study |
Keywords: | COVID-19;Post-acute COVID-19 syndrome;Respiration;Artifcial;Critical care outcomes |
Issue Date: | 2023 |
Publisher: | Springer |
Citation: | ROSA, R. G. C. et al. Association between acute disease severity and one-year quality of life among post-hospitalisation COVID-19 patients: Coalition VII prospective cohort study. Intensive care medicine, v. 1, p. 1, 2023. Disponível em: https://link.springer.com/article/10.1007/s00134-022-06953-1. Acesso em: 17 nov. 2023. |
Abstract: | Purpose: To assess the association between acute disease severity and 1-year quality of life in patients discharged after hospitalisation due to coronavirus disease 2019 (COVID-19). Methods: We conducted a prospective cohort study nested in 5 randomised clinical trials between March 2020 and March 2022 at 84 sites in Brazil. Adult post-hospitalisation COVID-19 patients were followed for 1 year. The primary outcome was the utility score of EuroQol fve-dimension three-level (EQ-5D-3L). Secondary outcomes included allcause mortality, major cardiovascular events, and new disabilities in instrumental activities of daily living. Adjusted generalised estimating equations were used to assess the association between outcomes and acute disease sever‑ ity according to the highest level on a modifed ordinal scale during hospital stay (2: no oxygen therapy; 3: oxygen by mask or nasal prongs; 4: high-fow nasal cannula oxygen therapy or non-invasive ventilation; 5: mechanical ventilation). Results: 1508 COVID-19 survivors were enrolled. Primary outcome data were available for 1156 participants. At 1 year, compared with severity score 2, severity score 5 was associated with lower EQ-5D-3L utility scores (0.7 vs 0.84; adjusted diference,−0.1 [95% CI−0.15 to−0.06]); and worse results for all-cause mortality (7.9% vs 1.2%; adjusted diference, 7.1% [95% CI 2.5%–11.8%]), major cardiovascular events (5.6% vs 2.3%; adjusted diference, 2.6% [95% CI 0.6%–4.6%]), and new disabilities (40.4% vs 23.5%; adjusted diference, 15.5% [95% CI 8.5%–22.5]). Severity scores 3 and 4 did not difer consistently from score 2. Conclusions: COVID-19 patients who needed mechanical ventilation during hospitalisation have lower 1-year qual‑ ity of life than COVID-19 patients who did not need mechanical ventilation during hospitalisation. |
Appears in Collections: | Artigo de Periódico (Educação Física) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
tclisboa.pdf | Open Access | 1,26 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.